Aromatase Inhibitors: Did you decide to go on them or not?

Thank you. Well said.
Bone loss is a huge concern for me. Unlike you I am going on at a half dose for 2.5 years if I can tolerate the drug. At 62 bone loss is a driver in the decision. Also researching enzymes, supplements that will stop estrogen creation without an AI

@katehanni and @eku, I see you have questions about the much publicized scientific breakthrough made at the University of Illinois, which was subsequently licensed by Bayer Pharmaceuticals in 2020. Early studies in mice seemed to show remarkable promise that led Bayer to invest $25 million exclusive global license agreement. Unfortunately, further trials in mice demonstrated that the promise was premature.

In a statement Bayer wrote in part: “Following a thorough assessment of ERSO in preclinical studies, Bayer has decided to discontinue development activities of this program for scientific reasons… we must take prudent steps to ensure the compounds have the potential to provide the therapeutic benefits we are striving to achieve for patients with cancer.”

Is is gut-wrenching when the media gives such hype to promising research discoveries in their very early stages. It can take 12 to 21 years for a drug to go from promise in test tubes to mice to humans to accepted new treatment. Many, many test tub (in vitro) and mice (in vivo) studies never make it to human trials.

I'm afraid that ErSO is one of those instances. The hope out of the hype is that the research has led to new approaches to study. You can read more here:
- Breakthrough metastatic breast cancer treatment hits snag https://www.thedenverchannel.com/news/national/breakthrough-metastatic-breast-cancer-treatment-hits-snag

The osteoporosis topic threads here are also very worthwhile. There is some comparing of supplements that people have found valuable in addition to the standard calcium/D3/K2 recommendations. Some are taking collagen, yet alone 5 kinds (about which I know zip). And a few have added boron to their protocol. I think the coolest thing though is the writers here using vibratory therapy. And it sounds like fun to me too, lol. I'll do anything to not have to watch my inner scaffolding become untrustworthy. I now think of grocery-lugging as weight bearing exercise and resent it less.

@katehanni and @eku, I see you have questions about the much publicized scientific breakthrough made at the University of Illinois, which was subsequently licensed by Bayer Pharmaceuticals in 2020. Early studies in mice seemed to show remarkable promise that led Bayer to invest $25 million exclusive global license agreement. Unfortunately, further trials in mice demonstrated that the promise was premature.

In a statement Bayer wrote in part: “Following a thorough assessment of ERSO in preclinical studies, Bayer has decided to discontinue development activities of this program for scientific reasons… we must take prudent steps to ensure the compounds have the potential to provide the therapeutic benefits we are striving to achieve for patients with cancer.”

Is is gut-wrenching when the media gives such hype to promising research discoveries in their very early stages. It can take 12 to 21 years for a drug to go from promise in test tubes to mice to humans to accepted new treatment. Many, many test tub (in vitro) and mice (in vivo) studies never make it to human trials.

I'm afraid that ErSO is one of those instances. The hope out of the hype is that the research has led to new approaches to study. You can read more here:
- Breakthrough metastatic breast cancer treatment hits snag https://www.thedenverchannel.com/news/national/breakthrough-metastatic-breast-cancer-treatment-hits-snag

I feel I’m in a similar position as you I’m scheduled for a lumpectomy on Friday, followed by radiation and then anti-hormone meds. I had a spinal fusion nine months ago and a knee replacement two years ago. I”lol be 68 in July. Menopause was horrible for me. I admit, I am very confused and scared.

I am finishing my 5 years after diagnosis but I had a no choice but double mastectomy DCIS. I agree with @windyshores. I was doing pretty well for the better part of 4 years. I would direct my yoga to where I was feeling pain or aches and it always made a difference. My doctors did prescribe Prolia for bones. Pain has been unrelenting for about the last 8 months so I recently stopped anastozole—only had to take it till end of May. I never fathomed being almost 70 now! My pain could actually be because I am 5 years older! But I am here…my recurrence odds are low, but who knows? Prolia also can cause aches and pains too, so it was a double whammy. I know people older than me who were on anastozole for 10 years and others who stopped after 6 weeks. You can choose to stop it unlike the cancer. Make sure you get a bone density test first. Check your vitamin D and work with an endocrinologist because they are experts about the pain and bones too. Wishing you peaceful decisions.

@jaynep, wishing you all the best for your upcoming surgery. You might find some tips helpful in these related discussions:
- Advice on Taking Care of a Spouse after a Mastectomy https://connect.mayoclinic.org/discussion/advice-on-taking-care-of-a-spouse-after-a-mastectomy/ (I know you're having a lumpectomy, but there's still some good stuff here.
- Exercise and Physical Activity after Breast Cancer Surgery https://connect.mayoclinic.org/discussion/exercise-and-physical-activity-after-breast-cancer-surgery/

With regard to the vaginal dryness, my doctor suggested Good Clean Love moisturizing gel. I use it twice a day and it has worked wonders. Maybe give it a try. It is on Amazon and isn't terribly priced. You definitely do not need much. The instructions say to use the applicator, which would mean using way more than you need, so keep that in mind as well.