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What problems have you had with Tamoxifen?

Breast Cancer | Last Active: Jan 25, 2023 | Replies (67)

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@katehanni

I had the bone and joint pain from the AI's and when I failed to tolerate them and moved to Tamoxifen there is still some residual joint pain which as I understand it is not the Tamoxifen. I have osteoporosis already and Tamoxifen is known to have a positive effect on the bones...I'm not a DR. so don't take my word for it! Just repeating what I've been told by my MD who was thrilled to find that I could tolerate Tamoxifen.

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Replies to "I had the bone and joint pain from the AI's and when I failed to tolerate..."

In a sense, tamoxifen has a positive effect on bones by not having the negative effect on them of total depletion of estrogen from the body. So estrogen remains available to perform the myriad roles it has throughout our lives. It just can't fuel estrogen-positive cancers because the drug prevents cancer cells' ability to access the cancer at the receptor level. They're both serious medications but, in a sense, the SERMs seem a more elegant approach by depriving only cancer cells, but not the rest of the body, of a key hormone. It's great that it works for you. It has saved thousands of lives so far, including two friends of mine.