i do not think a tortuous colon is like a mega colon. tortuous to me means it has a lot of areas that twist, mega means very oversized giving it way too much holding capacity. for me, reglan at bedtime creates a lot of stimulation to my gi tract. enough to keep me awake. i'm not familar with motegrity but it is prolly similar. miralax is too slow to work for me. i respond to it in about 3 days. it's a long wait. have you ever tried probiotics?