Once one is taking a new drug, or trying a new diet or making any change in one's life, it seems logical to assign that change to any other new changes one notices, but contemporaneous changes are not necessarily cause and affect. All of the complex things that would have happened anyway can, possibly, just be occurring on as they would have anyway. Having said that, I decided not to take aromatase inhibitors but 'could' change my mind. The one thing about taking them is that it's not an irrevocable decision as were radiation and chemo. As would be having anthing injected into the body, with a long, long half-life, which is one of my lines in the sand that I hope never to cross. That stuff can't be undone but one can try the drugs, and as others here have noted, try other brands or even a SERM if the side effects are discomforting. The downside, IF, one has a high risk of recurrence (which science cannot yet promise either way), is the lack of protection during time not on the drug. But that would be mostly offset by getting on it belatedly. My fear was of increasing the rate of bone loss because, honestly, the drug treatments for that condition, look like a Pandora's box of poor options and nasty side effects. And the accelerated bone loss was an absolute, not just 'possible, risk for the aromatase inhibitors as the resulting estrogen depletion is the driver. Thats not a popular statement but I hear from others with the same concern and want them to know others contemplate it too. And I've heard from people here whose oncologists failed to tell them about the bone density risk which is, to me, stunning medical negligence. But the fact is these are complicated decisions and, given others' personal risk choices versus one's own, easily confusing. Being willing to make them suggests an inherent courage that I hope is also reassuring.