@sunnygirl, if you're worried about his heart rate or if the symptoms worsen, please don't hesitate to go to the ER. The other symptoms sound like they can wait until you hear back from the oncologist, hopefully in the morning. Do you have access to contact your oncologist through a patient portal?

I'm tagging fellow members @nursed2075 @shaila1902 @taodeconnect @lynnycooks @flusshund who have experience with Tagrisso (osimertinib) and who may be able to give you more information. You can also read more in this related discussion:
- Has anyone taken the targeted therapy osimertinib (Tagrisso)? https://connect.mayoclinic.org/discussion/chemo-tab/

You said your husband has been taking Tagrisso for 6 months. How long has he had these side effects? Are they new? Did they start suddenly?