Don't give up hope. I have shared before that I would lay in my sleepless bed, getting randomly shocked every few seconds and I would analyse the best way to commit suicide. I couldn't live with this pain much longer. I needed to sleep. I only hung on because I loved my husband and knew he needed the "former" me. I also had the symptoms during the day, but they were not as dramatic and if I could distract myself with a project or television and get my mind off my misery it was helpful. I became obsessed searching the web and blogging with others trying to understand what was happening and what else to try. Histamines levels are higher at night plus no distractions while laying in bed.
Has she had the 5 Day Extended Patch Test? A trigger which began my issues was no doubt the memory foam mattress I switched to before I started having issues. This 5 Day test identified my contact allergens ( I have over a dozen which I now know the names of) one being an element in rubber which is used to process memory foam, yet polyurethane foam is made without it. I had so much to learn. Chemicals off gas and transfer though our skin and if allergic raise our histamine levels. This was seeping into me laying in bed. My clothes, bedding, cosmetics, metals, cleaning products, even my shoes and more were making me sick. MInd you, I was fine until middle age, no issues.
Steroids and Xanax are prescriptions which doctors prescribe out of desperation, they are trying to offer relief because they can't find a cause. I don't think that they don't care, it's they just don't have any answers. Yes they gave me Xanax thinking I was a hyper person, awful drug, it turned me into a zombie, I felt flat-lined. I only took it about 3 days, internal skin issues were no better.
As much as I hate steroids, to keep from losing her mind she should consider a Kenalog 40 corticosteroid injection. This would calm, eliminate my internal symptoms' for 9-10 months. My side effect was hair loss being about 2 months after the injection and hair regrowing after about 6 months. Also facial blushing lasted for months after the injection. This vicious cycle played on but kept me sane for 4 years until I began my anti-inflammation diet. If I had only tried it sooner.
I so hope she gets this invisible disease figured out. In summary get help identifying the cause- get to a good allergist or dermatologist licensed for the 5 Day Extended Patch Test, the True Test Kit is a common brand. Not all derms or allergist are licensed with the testing companies. Yet even after learning her allergen inflammation and the stinging still exists, begin an anti-inflammation diet, if that doesn't help after 6 weeks start up with steroid injections to temporarily calm the internal inflammation which she doesn't know the cause of. Don't get the test or the shots before patch testing because the reading wouldn't be accurate.
I so hope she gets to live pain free.