I started arikayce about 4 months ago. I was worried when I started because I had read about all the side effects. I’ve found the side effects to be very minimal. I had some hoarseness at first and still do occasionally but I barely notice it now. I coughed a little more at first but that subsided. I have asthma and it really hasn’t bothered me in that regard. I did notice after about 7 to 8 weeks a significant improvement in my breathing. I had been on the big three previously for 2 years and am back on them daily now. The addition of the arikayce definitely made a big difference. I’ve only had one culture since starting the arikayce and the smear came back negative but the culture still grew out mac but I have another sputum culture coming up and I’m hoping for a negative. I definitely feel much better than I ever did just being on the oral antibiotics. Also the process of doing the neb and cleaning it does take about 25 minutes a day but it’s really no big deal I work full time have kids and still manage to get it done easily.