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Aromatase Inhibitors: Did you decide to go on them or not?
Breast Cancer | Last Active: May 12, 2023 | Replies (1190)Comment receiving replies
One thing my onco-radiologist mentioned to me was: even though my risk of recurrence is 5% with the AI's and 6% on Tamoxifen (which I'm on) in the next nine years and my Oncotype score was 17 so no chemo. That said my tumor grade was 3 so when I was struggling with side effects from the AI's and I spoke to him he said "try to make them work due to the aggressiveness of your tumor. So although it was caught early, was small IDC I've been strongly encouraged to continue working through side effects (not as many for me with tamoxifen) and stay the course!
Has anyone on this chat board been made aware of the big discovery by U of I Urbana of the ErSO molecule that eradicated tumors in 3 days in mice and dogs and Bayer licensed it and intended to do clinical trials and it just disappeared with a small statement from Bayer about not moving forward with clinical trials due to "more scientific research" which of course needs to be done but sounds like they aren't moving forward with the testing of the drug....
In a statement Bayer wrote in part: “Following a thorough assessment of ERSO in preclinical studies, Bayer has decided to discontinue development activities of this program for scientific reasons… we must take prudent steps to ensure the compounds have the potential to provide the therapeutic benefits we are striving to achieve for patients with cancer.”
Promising research discoveries in their early stages may not succeed. It can take 12 to 21 years for a drug to go from promise in test tubes to becoming an accepted new treatment. Many test tub (in vitro) and mice (in vivo) studies never make it to human trials.
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I haven't heard about ErSO. Googled it and the story sounds interesting. There's a change . org petition to start a clinical trial for it. If anyone is interested, here's the link: https://www.change.org/p/systems-oncology-possible-breast-cancer-cure-drug/u/30162284
In a statement Bayer wrote in part: “Following a thorough assessment of ERSO in preclinical studies, Bayer has decided to discontinue development activities of this program for scientific reasons… we must take prudent steps to ensure the compounds have the potential to provide the therapeutic benefits we are striving to achieve for patients with cancer.”
Promising research discoveries in their early stages may not succeed. It can take 12 to 21 years for a drug to go from promise in test tubes to becoming an accepted new treatment. Many test tub (in vitro) and mice (in vivo) studies never make it to human trials. I