I see that EB-N6 and Metanx have several B vitamins in common, but additionally EB-N6 contains B1 and Alpha-lipoic acid. I glanced quickly at such products as BioSoothe pro and VitaSoothe pro, and noted that both contain the same B vitamins as well as D3, but additionally BioSoothe contains B1 (learned, too, that the exotic sounding Thioctan is Alpha-lipoic acid). Protocol 525 is another B vitamin supplement, but more complex, with several other ingredients that likely promote nerve health.

My completely unscientific opinion as to why some work better than others is that people have differing needs of vitamin B supplementation. Metanx might be just fine for some folks, whereas other folks might need that ALA in EB-N6, not to mention that still other people might benefit from the hemp oil in the Protocol. That's why, I guess, people have to try different products....some that are already formulated, or dose themselves experimentally with various B vitamins combined with, say, D3, Mg, etc.