For me it was quick working for sure within a month. I was very grateful for Orencia. Not one side effect. I probably would still be on it but for some reason after a period of time meds stop working for me. But Orencia worked longer than anything. I sure hope you have my experience and I think you will since you have already been taking the drug. The nurses that gave me the infusions were very knowledgeable and had no trouble sticking me and I am a very tough stick. Good luck.