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Feeling tired! Do others with PMR feel significantly more tired?
Polymyalgia Rheumatica (PMR) | Last Active: Jun 1, 2023 | Replies (75)Comment receiving replies
@lcb2021, I can tell you feeling tired was a definite yes for me when my PMR was active. Here's some information on the topic.
"Why does PMR make me so tired?
Conclusions: PMR patients were significantly more likely to have had multiple fatigue consultations before being diagnosed with PMR. Given the overproduction of inflammatory cytokines seen in PMR, this fatigue may represent a prodromal phase prior to consulting with more classical musculoskeletal symptoms." --- Fatigue as a precursor to polymyalgia rheumatica - PubMed: https://pubmed.ncbi.nlm.nih.gov/25366389/
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A little copy and paste ----- Why prednisone causes fatigue
Prednisone is more powerful than your body’s own cortisol. This means that prednisone will outcompete your own cortisol for receptor sites in tissue.
When you take prednisone over the long term, your body goes through a phenomenon known as feedback inhibition. The extra cortisol from the prednisone tells your body to stop making its own cortisol.
If this continues for many years, the part of your adrenal gland known as the zone fasciculata will shrink. If this occurs, not only will you be profoundly fatigued, you will need glucocorticoid drugs to keep your cortisol levels up. Your body can no longer create its own cortisol.