Hi everyone, This is my fourth episode of PMR 1n 10 years - groan. For my last session in 2018 I had difficulties in weaning off prednisone and the methotrexate seemed to help. I've attached a graph which shows on the X axis 'time since onset' and the Y axis shows the values. It shows that each time I tried to decrease the prednisone I had an increase in pain. The medical text "UptoDate'" has this to say about using methotrexate to help reduce prednisone "Data from randomized controlled studies on the efficacy of MTX as a glucocorticoid-sparing agent are mixed, though generally favorable results have been reported with regard to cumulative glucocorticoid doses, relapse rates, and time to discontinuation of glucocorticoid treatment [42,43]. Interpretation of a negative controlled study on the use of concurrent MTX is limited by a high dropout rate [44]. These data, however, are limited by several factors including the small number of patients studied and by the relatively low doses of MTX used (in the range of 7.5 to 10 mg/week) compared with contemporary doses (in the range of 20 to 25 mg/week). Also, no study has demonstrated an actual reduction in glucocorticoid-related adverse events in MTX-treated patients compared with patients treated with glucocorticoids alone." For my present episode, I've started again on methotrexate to hopefully reduce the total time on steroids - keeping my fingers crossed! However, the methotrexate does require monitoring and frequent blood tests. Oh, and booze not allowed 🙁 Hope this helps.