I take mine at night with my cholesterol med (genetically high from my mom). My PC told me to take the cholesterol drug at night because it works better when you’re at rest; and my medical oncologist told me to take the Anastrozole at night because if I was going to have joint issues, etc., at least I’d be asleep through several hours of it. Sounded like a plan, so that’s what I do.
I talked to my radiologist about the reduction (I’ll double check with my breast surgeon when I see him in a week and a half); but he said I should wait about a year after I’ve been through the cycles of blood work, mammograms, etc. plus he said that a good year of healing my body can’t hurt before subjecting it to another surgery.
I’ll definitely take my breast surgeon’s opinion about that above all others.
I have been blessed with excellent doctors along the way who encourage questions (I often show up with a notepad full - lol); but every one has been willing to do what all cancer patients need - to be heard. I love the team I’m associated with on this journey. They have always cared about my feelings and will spend all the time I need so that when I leave there, I’m more knowledgeable and therefore less anxious about what to expect. 🙂

It's my understanding that depleting the body of estrogen speeds up lose of bone density. Is that incorrect? If non-SERMS deplete estrogen, including estrogen that the body continues makes post-menopause, then in fact bone loss is greater than if one had not taken the aromatase inhibitor. And that side effect, while hopefully ameliorate by other drugs to offset it, is a given.

The exacerbated bone loss issue is in fact a side effect that alarms so many women and one study suggested it accounted for more than 30% of the double-digit rate of non-compliance with regard to adjuvant hormone therapy that the breast cancer studies that I've read cite as the current best-guess rate. [The non-compliance rate was derived from doctors reporting it as well as meta data analysis of prescription refill requests falling off over time. The inference was that these patients generally had insurance or financial ability to continue care and afford prescription co-pays so the non-compliance was more likely due to undesirable side effects.] I would be happy to find that I'm wrong in this understanding about the effect of AIs it is a primary variable in my decision. Thanks in advance.