Hi @neasrenrut, I would like to add my welcome to Connect along with @amandaburnett and other members. Your post was moved to this neuropathy discussion that has posts about calcium, B-6, neuropathy issues - B-6 vitamin danger!: https://connect.mayoclinic.org/discussion/b-6-vitamin-danger/

There is also another discussion that might be helpful
-- Calcium Scan: https://connect.mayoclinic.org/discussion/calcium-scan/

You mentioned your CT scan was 653. Here are a couple of references that maybe helpful with information related to your CT scan results:

--- "Over 400 Extensive evidence of CAD" Cardiac CT for Calcium Scoring: https://www.radiologyinfo.org/en/info/ct_calscoring
--- "The multivariate analysis revealed that the presence of CAD was a statistically significant risk factor for ischemic peripheral neuropathy." -- Prevalence and Risk Factors for the Peripheral Neuropathy in Patients with Peripheral Arterial Occlusive Disease: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4480317/

I'm not a doctor and have no medical training but I'm not sure anyone can answer your first question will the painful neuropathy decrease with lower cholesterol numbers but my guess is that it would take more than lowering the cholesterol numbers. Your second question is really a good and one you should discuss with your doctor. My doctor has wanted me on statins for a long time but I'm not about to start them because I have neuropathy and do not want to make it worse. I might think differently if I had a condition that would put me in a higher risk. Then I would have to weigh my options and discuss with my doctor. There are things you can do to lower cholesterol naturally but you really have to work at it. Mayo Clinic has a good place to start - https://www.mayoclinic.org/diseases-conditions/high-blood-cholesterol/in-depth/reduce-cholesterol/art-20045935

Are you on any treatments for your Hypercalcemia?