I am very familiar with this discussion. I was diagnosed with Luminal A (Stage 1A) IDC last summer, had a lumpectomy followed by whole breast radiation. The radiation brought my same breast recurrence rate down to 1.7%, improved slightly to 1.3% with hormone adjuvant therapy. My Oncotype score is 8, estimating distant recurrence to 3% with an AI or Tamox, or 5-6% without. Because I have progressive osteopenia, I opted for tamoxifen. After taking a lesser dose for 4 months I started to experience very debilitating joint pain, which affected my gait and my yoga practice, as well as horrible night-time leg cramps and depression. I also feared both DVT and endometrial thickening. I stopped the tamox last week. As a very active and trim 71 year old, I wonder if the benefit of taking an anti-estrogen drug for 5 years outweighs its toxic side effects. I also understand that estrogen positive BC recurrence stretches beyond 5 years. Here's a good article: https://www.verywellhealth.com/late-recurrence-of-breast-cancer-4766608 I have an appointment with my by-the-book oncologist and another one for a second opinion with a breast cancer specialist to discuss my options. Will I take tamox again, this time in the a.m. as opposed to the p.m., or try Armidex/anastrozole? Very possibly. In the meantime I am changing my diet to support my immune system. Anti-Cancer: A New Way of Life is an inspiring book on how diet can reduce cancer risk.