@Joanne, @eileen, hi ladies. I also have gastroparesis but not as bad as the two of you. Please forgive me for butting in. I also have taken Reglan, didnt do a thing for me, also Zofran, nada. I have had IBS-C since I was 20 and married my first husband. I'm 70 now. Have been depressed off and on for many years and tried many antidepressants. My psychiatrist is trying me out on some antipsychotics bc I see things. Trouble is these meds cause constipation. If it has that side effect I will have it. The first 2 I threw away. Eileen, I thought I was the only one that researched my conditions but you have beaten me hands down. I'm so impressed. I think maybe my pcp has forgotten I have gastroparesis. I have a really bad case of all over body itching and that's what I mostly am looking up. Ladies please 🙏 take care of yourself anf God bless. Dannybee