Hi @queenie2030 have you spoken to your doctor? Do you have a rheumatologist? The prednisone is supposed to decrease inflammation dramatically. Maybe there's something else going on, causing the inflammation, that isn't being addressed by the prednisone. My aunt had Giant Cell Arteritis. She was taking prednisone for it, but she also had an absess in her GI tract that was not diagnosed because the prednisone masked her symptoms.
My Rheumatologist only goes by the CRP. He doesn't think the ESR is accurate. My highest CRP was 10.6, with Giant Cell Arteritis, before I went on Prednisone. Now it's down to 1.2 (on 4 mg of Prednisone). All the best.

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