Diagnosed in late 18. PSA of 29, cancer in all biopsies. 24 months of Lupron [3 month shot] with 44 treatments of radiation. I am now 65. As you say, radiation is not the problem. Before being diagnosed, I could walk 18 holes and mow the yard the next day. Now fatigue takes its toll still with hot flashes and weight gain. Quality of life? I am still alive and grateful for that. I still do what I want to do in moderation. I have great support from family and friends. I heard that for as long as you are on Lupron, it will take that long after to get over side effects. Myself. I am looking forward to the end of this year.