I’ve been taking it for over a year and the time has changed a few times due to hospital stays and ER visits. Most recently I went to the ER for an anxiety attack. I was having trouble breathing and my heart rate was very fast. I take it for DVT blood clots in my legs. I was given my dose 3 hours late while they tended to me. I remained on that schedule for about a week but then I started falling asleep and taking it late by an hour or 2. So I did end up changing my time from 8pm to 6 pm by taking it 2 hours earlier. I’ve been consistent with that. My previous time was 5pm for a long time. Thank you for replying. Any feedback and help is greatly appreciated.