@buckslayer I can't address whether Mayo uses Onivyde. My wife's treatments have been at Johns Hopkins and locally at Advent Health Cancer Center in Central Florida. Onivyde was actually first approved in 2015 and is the only chemo agent which is specifically approved for pancreatic cancer. All of the other agents, 5fu, leucovorin, irinotican, oxalyplaten, cisplaten, gemcitibine, abraxane etc are all generic gastro chemos and have been available for decades. We only learned about Onivyde when I insisted that my wife be put back onto folfirinox because the GAC and GA treatments had failed but her original folfirinox treatments had actually gotten her CA19-9 below 30 and the primary tumor was necrotic when they opened her up. After 2 onivyde treatments my wife's CA19-9 was down by 59% and we're hopeful that we see additional significant reductions and that the previously identified tumor has stabilized or shrunk by the next scan. Good luck to you and hopefully your doctor has other options or trials available.