I am not sure what you mean by your question on low dose Reclast protocol. I am currently on Tymlos. My doctor knows I am very sensitive to meds. After Tymlos he thinks I may only need a maintenance dose of Reclast and may even be able to go on and off of it. So he mentioned doing 1/4 dose. I would drink a lot of water, take tylenol and they would infuse very slowly. He would monitor my bone density/loss and adjust treatment accordingly. This all depends on my results after one year of Tymlos. I may continue on Tymlos, or Forteo (which can currently be taken longer) or add Evenity if my osteoporosis is still severe.