I'm on the methotrexate 2.5= 8 tablets a week with prednisone 5.5 mg. I felt pretty good, and when I went up to the max methotrexate at 10 tabs, I felt 20 years younger (I am 69). WOW! Unfortunately I ended up with thrush (candida) and a tongue ulcer, so I took the medication for thrush and backed down to the 8 tabs. I won't forget how good I felt, though. I am doing pretty well with the 8 tabs and backed down to 5mg prednisone. Hoping to slowly back off the prednisone, and then the methotrexate. Who knows. Judy