So, when I was on Prednisone I went on Methotrexate and then Actemra. I could not tolerate either one. Two weeks ago, I was switched from Prednisone to Hydrocortisone. I started at 20 mg in the AM and 10 in the PM. I felt awful and so the endocrinologist upped the dose to 25 in the AM and 15 in the PM. Again, I was miserable with night sweats, pains in my arms, shoulders and neck, plus headaches and extreme exhaustion. Today my doctor upped the medication to 30mg in the AM and 15 mg in the PM. My endocrinologist said that things would be brutal. He was right!