I too have been diagnosed with collagenous colitis, a miserable condition. None of the oral medications have given me any relief so the specialist wants to start infusion therapy (waiting on approval from Medicare). My weight has gone from 170 lbs to 121. It has changed my life and made me almost a recluse due to frequent trips to the bathroom and many accidents. Let me know how the medication works for you.

@fdixon63 - I was diagnosed with collagenous colitis 13 years ago. I was initially treated with Methotrexate injections that stopped the non- stop diarrhea. Budesonide should also work.
It is an autoimmune condition- - a trigger, such as a medicine, was never found.
The autoimmune intestinal condition returned, but without the continuous diarrhea. I was later treated with more immunosuppressive medication.
In your case, I would try the Budesonide. It is safer than Prednisone because it’s not absorbed by the body

This website was very helpful to me when I was diagnosed with microscopic colitis, which went into remission a few years ago. https://www.perskyfarms.com/phpBB/index.php
Lots of information here. I took Asacol for many years, which was helpful. Best to you in dealing with this frustrating disease.

I was diagnosed with Collagenous Colitis - CC in 2009. However, I'm pretty sure I was dealing with it long before then. I'm at the Budesonide - Steroid point now after going through the Pepto Bismol regimen last year. With a significant weight loss - 40 pounds - probably due to malabsorption of nutrition in my gut, I'm on a pretty gluten, dairy, etc. free diet. Take several supplements to make sure you have some nutrition. This disease also makes me very angry because the GI doctor community does not support a potential of food intolerance or trigger foods. Thanks to Mayo for at least recognizing there is something more than drugs to help live with this disease.

I would suggest you take Budesonide for several months. Only problem, it's quite expensive, so look to GoodRX and Single Care for help with the cost.

I have had CC for many years. At first, I took many of the meds already mentioned here - which did not help. I went to a different gastroenterologist who prescribed OTC Imodium. As simple as that sounds, it works for me. I take 2 - 2 mg tabs: 1 in AM and 1 in PM.