We, I, am here to support you and your wife in any way we can. I have only gone thru one surgery and recooped well other than the tough gut issues for ~6 weeks. I had to come off Folfirinox after 4 txmt's because my platelets couldn't keep up. We tried gemcytobine but it too impacted platelets. Then like your wife, I went from clean to metatesis to the liver. I have a rare genotype of Kras G12c mutation that occurs in 1-2% of Pancan. and it loves to become resistant to treatment. I went on a combo clinical trial with Amgen 510+ another+ monoclonal that targeted my genotype. Responded for 2 months and then the lesions became more pronounce so discontinued from study. I am now on Folfirinox liposomsal + Leucovorin+ 5FU. Tehy dropped the platin to try and avoid such a negative impact on platelets. So far good on platelets but with the progression of this disease I do have low hemaglobin and albumin. Will have my first CT on this tx in 2 wks. Don't expect big response but hope it keeps it in reasonable check. The clinical trial was rough as my skin broke out everywhere and got infected and became very sensitive and still is on face and arms.
I am so sorry your wife can't get some relief and didn't mean to imply that you had not tried many things. I just wanted to pass on things I had tried along with my team's guidance and what helped. I was not a very active person physically so it didn't hit me as hard on not being able to run or walk a lot. I do walk more now because it helps. I was very active in community service organizations and hands-on donation of my time and having to tune that back has been a challenge but I try to balance the physical efforts with the mental satisfaction it gives me. I volunteer to do more admin things at home if I cannot do the physical tasks. My husband does some light massages to my back as needed and it helps relax my tenseness. Keep your head as far above water as you can and do give yourself a break. Your team will benefit.