My cholesterol levels responded to Bergamot extract. My son who lives in Australia was put on it by his physician. It's an Italian citrus fruit, so I'm thinking it's effective because of its polyphenol content. But if you're taking any medications that say not to eat grapefruit, you shouldn't use this either. Its effect in increasing my good cholesterol was even more dramatic than my lower bad cholesterol numbers. It had the most stunning effect in lowering my triglycerides. Then I cut out white flour foods (pasta and bread) and red meat and my numbers got even better. Then I started walking for 20 minutes a day and they got better again. Right now I'm dealing with chemo-induced neuropathy, and I'm working my way through the long list of treatments that have been studied. It's been 18 months since I completed treatment. I'm still tingly with deadened feeling, but my fingers and toes no longer hurt to the touch, and my toenails that fell off have grown back.