We are just starting Creon and it is a hard one to figure out. My husband is a month and half since his surgery. They couldnt do a Whipple so they left the tumor and did introperative radiation. Since then his digestive issues have worsened so we are wondering if pancreatic insufficiency is at least part of the problem. In addition to the cost, the amount of Creon needed can be individual..so far my husband is not getting much benefit and still has to take opiates and maijuana for relief from stomach pain.. Does anyone have any experience with other forms of PERT??