My PCP prescribed Pioglitazone several years ago while at the same time referring me to an endocrinologist for treatment of my diabetes. At my visit in January (I go every three months for A1C, etc) the PA discontinued the Pioglitazone because it causes fluid retention & weight gain! I asked her why then had no one taken it away sooner? I've taken it for several years! Very frustrating when even with regular evaluations of medication the physician or his PA aren't sharp enough to stop a medication that wasn't doing me any good & was doing harm. I've told the PA my legs ache. The PA ordered a circulation test which showed the circulation is normal for someone my age. The PA had no solution to offer since the test was "normal." That doesn't mean my legs stop aching though so now I'll ask the PA about the statin. I take Atorvastation and Ezetimbe.