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Beginning prostate cancer treatment

Prostate Cancer | Last Active: Mar 13, 2022 | Replies (52)

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@upnort

Thank you very much for your prompt, detailed response.
At the time of my prostate biopsy in November, my PSA was 7.4
The cancer is contained within the prostate - no eveidence of perineural invasion.
I am considered to be in the unfavorable intermediate risk group: Grade 3, Gleason score 7(4+3)
My Pelvic MRI in December confirmed cancer limited to prostate only - no boardering tissues/glands/organs.
In mid-January, my radiation oncologist recommended a six month hormone therapy - bicalutamide and Lupron* injection - along with EBRT(moderate hypofracionation -which is considered by national guidelines to be the current standard of care for many men with localized prostate cancer). *It looks like Orgovyx was approved by the FDA in late 2020 for High Risk prostate cancer patients.
I am currently waiting to hear from Mayo Clinic on a second opinion as to the above proposed treatment plan.
In addition to my new cancer diagnosis, I have been dealing with a type of myelopathy since 2017. The lesion on my spine is of unknown origin and has affected my lower extremities: numbness and tingling from my toes up to my waist. I was a neurology patient at Mayo Clinic in Rochester(I live in Wisconsin) for two years. After dozens of tests and failed medications, I was recommended to the UDP - NIH in Bethesda, MD.
I was accepted last year, but the program has been paused during COVID. I have since been under the supervision of my local nuerologist until I can be seen by NIH. My current diagnosis is neuromyelitis optica (NMO). I am presently receiving two infusions of rituxin every 6 months. No improvement in symptoms to date ( four years ago I was running 4 miles a day. Today I have to use walking sticks to get around, with my mobility and balance continuous issues affecting the overall quality of life).
I also have chronic osteoarthritis in my left knee, compounding my mobility issues. I am a candidate for knee replacement, but only after the NMO is addressed.
I am also the primary care giver for my wife, who is in Year Seven of Alzheimer's disease. This has been absolutely devastating, as we have been married 47 years. I need to be at my best - physically/emotionally - for both of us.
Throw in COVID and we have the perfect storm.

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Replies to "Thank you very much for your prompt, detailed response. At the time of my prostate biopsy..."

I can relate to your perfect storm comment. A couple of years ago I did the 2 years of Lupron along with 43 treatments of Proton Radiation Therapy for my aggressive and advanced prostate cancer. I have been done with the Lupron for a year now and can report that my psa and testosterone numbers are good. However, I have now been diagnosed with Myleodysplastic Syndromes (MDS), a form of blood cancer. Radiation oncologist claims that this was not caused by the PRT, but I am not convinced. In any case, I have it and will be starting down that journey for myself while also being a caregiver for my wife of 58 years who has Lewy Body Dementia (LBD) - similar to alzheimers. And then there is the covid too.

Given what you describe as to your health situation, the six months of ADT may be challenging whichever drug you use. The side affects are generally the same.

Here's a link which may show you are making the right decision- https://www.practiceupdate.com/c/131474/2/3/

I would ask your medical team about using Orgovyx, my medical team has never talked about it being used only in high risk, they use it in patients like you with other health risk factors because of the reason I listed.

As to the advice about exercising to mitigate the side affects,, not sure thee, perhaps your medical team can consider a physical therapist who can design a specific program for you?

Sorry to hear about your wife, it's not how any of want the "to death do we part" portion of our vows to go.

Kevin