I know there are many possible side effects of Prednisone, and I would rather not take it. However, after starting at 10-12 mg Prednisone, I was almost PMR symptom free within 48 hours. Now, 6 months later, I am at 2 mg. I have not had any serious side effects (except perhaps tinnitus). I am starting to feel some stiffness again, but hope that my body will adjust. I feel like the Prednisone has given me a new lease on life. Best of luck!