I have been on Tymlos for 5 months but I started at 1/4 then 1/2 dose for the first month or more. Yes there are side effects but they improve over time. I suggest you google all the medications and learn about them. Biphosphanates like Fosamax (oral) and Reclast (IV), like Prolia, suppress bone turnover. However drugs like Forteo and Tymlos actually grow bone (but don't suppress turnover, so bone quality is good). Evenity does both. You also need to check insurance coverage - you may be eligible for Tymlos, Forteo or Evenity now that you have "failed" Prolia. But your choices also depend on what your bone density score is. You haven't told us how severe your osteoporosis is.