@sikocesca, There are a few discussions where members have shared their experience with Low Dose Naltrexone (LDN).

-- Low-Dose Naltrexone for Chronic Pain: https://connect.mayoclinic.org/discussion/low-dose-naltrexone-for-chronic-pain/
-- Success with low dose naltrexone for Autoimmune disorders: https://connect.mayoclinic.org/discussion/anyone-familiar-with-low-dose-naltrexone/
-- Anyone with experience using Low Dose Naltrexone?: https://connect.mayoclinic.org/discussion/anyone-with-experience-using-low-dose-naltrexone/

@mywits I too had knee replacement surgery. I complained that the socks I had to wear after surgery were too tight. I also had a hip replaced years ago and don't remember the socks feeling that tight. I was told I had to wear them to prevent blood clots. When I would remove the socks to shower, I could not feel my feet. I told the doctor and he said he never heard of such a thing. I was later diagnosed with peripheral neuropathy. Before the surgery I had no problem with my feet.