Hi @abbeyc the information sheet on Prednisone says "Some products that may interact with this drug include...NSAIDs such as aspirin/celecoxib/ibuphrphen." It says that if your doc has directed you to take low dose aspirin, continue to take it, unless your doctor directs you to do otherwise. I do take low dose aspirin because people with GCA are at high risk of developing aortic aneurysms down the road. Maybe best to check with your doctor or pharmacist if it is okay to take the ibupprofen. Tylenol doesn't reduce inflammation, but relieves pain. The prednisone is supposed to reduce the inflammation.
Always take the prednisone and Ibuprofen with food. Take care, Teri