My Neurologist said to take 1 capsule twice a day. My pain and tingling symptoms improved after I decreased the statin dose and then went away within two months of taking the SuperiorLab brand of ALA, which has 600 mg per capsule. The Neurologist said I needed to take it for at least a year. After a year, he said I could continue the dose, but I decreased it to 1 capsule. I have no pain. My brother’s severe peripheral neuropathy pain improved within 6 months. He tried stopping it after a year and his pain returned, so he resume taking it. He had tried all the traditional drugs prescribed, but ALA works the best for him. He is not on any pain medicines now. Check with your pharmacist or doctor to make sure that ALA does not interact with any of your other medications. Hope this helps.