There is evidence that people with PMR should take their prescribed dose of prednisone later in the day, even just before bed. After my PMR Diagnosis I was taking 15MGM of prednisone in the morning as directed by my rheumatologist and it wasn’t working after three days. So I switched to taking it before bed and bingo the next morning I felt great relief. I now take it after dinner so I am taking it with food to reduce digestive problems and it works well for me. The study I said inflammation occurs at night and you need the prednisone most at 3AM so you quell the inflammation and wake up feeling less stiff and sore. Just food for thought. Best wishes to all for good results.