@jr2366 Jennifer this is Irene responding . I am sure Colleen will as well. Arikayce does make many of us lose our voices, but it does come back. If you take a break for a few days that should do the trick. It did with me, but I told the pharmacy and my ID doctor. Make sure you tell them if you do that. And those lozenges are fine. In fact any soothing sore throat lozenge is better than none. You also should probably ask your doctor why he put you on Arikayce first. Arikayce is a good drug for MAC but should be used in conjunction with other MAC meds. As a funny aside to your plight my husband always tells people he married me fifty years ago because he would never have to say another word. He is a quiet one, and I am a social person. When I lost my voice I think he was glad because I couldn’t nag him as much. It also helped me limit calls with my children who I love dearly but who call 24/7. Anyway, I think you will be good to restart if you stop for a few days. But talk to your infectious disease doctor or email him or her first. irene5

You won't. It may happen from time to time for a day or few days. Then it magically comes back. Gargling after treatment with warm salt water is helpful. Please don't worry.