Both my girlfriend and I have had BC twice and are currently taking anastrozole. We are both 70+. Neither one of us have had or are currently having any issues with this medicine. Both of us are active and get plenty of exercise. I walk 3 miles/day weather permitting and knit which I think may help my hands AND we both take our medicine at night. We were just talking about it the other day. She said her doctor advised her to do it that way. It is worth a try.