Cut out sugar in all forms ( including bread,) use almond flour. No diet drinks. I did a strict diet plus red light therapy. One can get a good light at sgrow they are on Amazon. I use a lot of natural supplements. Try Mega Benfototiamine & Optimized Carnatine the first is a form of B-1 but can penetrate.bllod/ brain barrier the latter is a amino acid. If you are interested private msg me I will be glad to tell.you where I get mine from and why