Well Tamoxifen was the original SERM developed to coat the estrogen receptors so that no cells/cancer cells can stick to the other cells thereby preventing tumor growth and formation. The Aromatase Inhibitors have a completely different method of action which is lowering your estrogen levels to almost undetectable levels (and significantly increasing testosterone levels) which for me made my personality completely change so I'm relieved that I can tolerate tamoxifen. I know the AI's are the silver bullet but I had particularly toxic reactions to them.

I also have intermittent sensations of a bladder infection with the tamoxifen but I don't have a bladder infection so I think it's just a side effect that is not life threatening!

I don't know what to say about the polyps. Are they in your bladder or breasts?

Aunty Oakley is totally right about all she said. It's so important that we give ourselves a break. I have a C Suite Executive position at a health care non profit and my memory is better now on Tamoxifen, but still experiencing some short term memory loss so I also am just going with it, and moving forward. If I need to retire, then I will. It's all about my health now!

I wish you the absolute best!

Kate