@migizii Hello. This disease bronchiectasis and it's subsequent issues of mac can progress at various speeds. Some are very rapid, others so slow that people die of something else, or natural causes. There are many variables. For instance, are there other co-morbid diseases present (like pulmonary hypertension, Alpha-1, pulmonary dyskinesia, emphysema, Cystic Fibrosis, etc.). These other co-morbid diseases can help to drag a person down, making it hard to fight off bacterial infections. Some patients also have immunity issues. Some people live in areas where they are receiving extra heavy bacterial loads of mac and/or pseudomonas. Another factor that can affect outcomes is becoming resistant to antibiotics. It is very important to follow an antibiotic regimen.