@kathyhg I may have shared this with you before, but I have never been on the 'Big 3' for treatment of mac. I was put on alternating months of cipro and doxycycline for two yrs in 2013. I would take them for ten days each month. My mac cleared after one year . Then I got pseudomonas in 2016 and the doxycycline was replaced with inhaled tobramycin. that cleared my pseudo after 30 days. I remain on the tobramycin and cipro to this day. I take these on alternating months. After taking the first toby treatment, I was cough free after 28 days and remain good to this day. My regimen will not work for everyone because it will all depend on one's susceptibility test. BTW, I want to remind everyone to keep a hard copy of your susceptibility test and lab results for sputem.