Thanks for your response. You’re right, Xeloda isn’t a new drug but according to my oncologist using it after radiation, like in my case, is fairly new she said. I have neuropathy that developed during my AC-T chemo therapy and I continue to have it 5 MOs after the initial chemo treatment. I take medication that relieves the nerve pain. From what I’ve read about Hand/Feet (or foot) syndrome it sounds much worse than just hot/cold sensitivity (which I don’t currently have) and can include peeling and blistering skin, cracking and in severe cases may make it difficult to wear shoes and walk. That’s what I’m most worried about and not being able to use my hands. Yes, I’ve discussed this with my dr but she left the decision to me so I’m trying to get as much info as I can.