Kathyhg, I cannot take the big three because of a heart condition called atrial fibrillation. 2 of the big three cause atrial flutter and rapid heartbeat and put me at risk for stroke. Also the xarelto that I take for blood thinning is contraindicated with the big three drugs. If you are having heart issues with the big three then you may need to check in with a cardiologist to find out why. My best wishes to you.