I have been taking tramadol 50mg (one or two a day) in addition to pregabalin and oxcarbazepine. It really does take the edge off of my small fiber neuropathy symptoms (aching and burning). I usually only need it at night and sometimes only take one tablet. I have the same concerns as you do about dependence and I suspect this is a healthy position to take. As with any opioid, tramadol has the potential for dependence and abuse. If you have previous tendencies toward abuse, as I have in my past, you need to be mindful of this and open with your doctor.

I am NOT dispensing any medical advice but I will offer these points that you should research on your own and discuss with your doctor.

I noticed that my mood in general seemed to be lifted, but not to be confused with euphoria. So I started doing some searching on the internet and there does seem to be some evidence of antidepressant properties with tramadol.

In addition to the concern of dependence, I would also be concerned of serotonin syndrome if already taking antidepressants.

I take quite a number of meds for diabetes, blood pressure, cholesterol, thyroid, blah, blah, blah, so I am always searching for potential interactions. My doctor is great, but like most medical professionals he is overwhelmed with a huge patient list. You are you own best health advocate. Do lot's of research on the internet, but be aware that the internet is loaded with information and disinformation. Take what you find and consult with your doctor.

Best Wishes!

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