Thank you for your reply as I am having a hard time with this new and different diagnosis. I don't have answers to some of your questions as this is still undergoing some testing. I was diagnosed with lobular carcinoma in 1998, followed by a left breast mastectomy and 6 months of CMF chemotherapy. In 2000, I had a local re-occurrence under my left armpit, which was attached to my skin. After surgery, I had 6 weeks of radiation to my left chest wall. I took Arimidex from 2000 to 2013, at which time I had to switch to a new oncologist, who took me off of the Arimidex as he felt that it was probably not needed anymore, nor was it effective any longer. ((my previous oncologist said that he would keep me on it for life.) In 2017, another lump appeared under left armpit, which was more lobular BC. It was removed with clean margins. In 2019, I underwent a R breast mastectomy as the lobular cancer had now shown up in that breast. I was put on Tamoxifen, and in 2020, 2 more lumps showed up under armpit on left side. I had a surgery that required a left dorsal flap to close the wound. After a long period of healing the wound from that surgery, I had 6 weeks of radiation on my left chest wall. The side affects of that have been very uncomfortable as my whole chest wall is bound very tight making harder for me to expand tissue and the right lung. I was put on Abemaciclib and Falsodex for treatment (extremely expensive medication!!) in June 2021; meanwhile I have 4 more small pink dots on my lower right chest wall. 2 were biopsied and show more lobular breast cancer. One of them grew to a small sized pea, which was removed and biopsied. That has come back as Triple Negative breast cancer, different from all of my past ER positive breast cancers. That was a lengthy answer to your question about my history. It is long and thank you for reading all of this. Although this is past history, I ask myself if I had not been taken off the Arimidex in 2014, would any of this occurred, as I was symptom free for 14 years. FYI, my oncologists are at Stanford in Palo Alto, California.

The clinical manifestation of triple-negative breast cancer is an aggressive course, with a higher risk of distant metastasis, a higher chance of visceral metastasis than bone metastasis, and a higher chance of brain metastasis. The risk of distant metastasis of triple-negative breast cancer reaches its peak at 3 years, and may decrease thereafter. The median tumor size of triple-negative breast cancer is 2 cm, and 50% have lymph node metastasis. The histological grade of this type of breast cancer is mostly grade 3, and the proportion of cell proliferation is relatively high.

Treatment
There are no specific treatment guidelines for triple-negative breast cancer. Therefore, its treatment is generally carried out according to the conventional standard treatment of breast cancer.
1. Chemotherapy
Compared with other types of breast cancer, chemotherapy is more effective for triple-negative breast cancer, but if it is just a conventional standard treatment, the prognosis is still very poor.
2. Adjuvant chemotherapy
FEC sequential docetaxel chemotherapy has a better response. Taxanes have a certain effect on triple-negative breast cancer. Platinum drugs may be more effective in triple-negative breast cancer. Cisplatin neoadjuvant chemotherapy is quite effective.

im in very similar situation.had er pos 21years ago...now surg for 3Nbc...now margins/nodes all clear...not anxious to do rec chemo prefer holistic supps,diet,exercise