Hi Phyllistamara! I have been on these drugs for over 4 months now - started on October 1, 2018. I have had to play around with the times of day that I take them. For me, it works if I take them right before bedtime. I sometimes wake in the night with cramping; but sometimes do not. I think that mostly has to do with what I ate during the day - green salads, fried foods, and dairy products tend to upset my stomach more than others (which is sad because I love green salads!). I try to eat more carbs than I did before - which helps settle my stomach. And drink lots and lots of water.
I also go to the eye doctor and have my eyes checked every 3 months while on the big 3.
So far so good!