I have a terribly sensitive gut. Have trouble with most things other than Tylenol. Still stupified that I do so well on the meds. I started them a week apart both times which helps immensely. And again, if your doctor is willing to let you suffer with them and not keep tweeking, you have the wrong doctor. My doctor in Texas is invested in seeing that I have the best life possible at all times. When he tried a new med on me and it put me to bed, I called him and he said "Throw that damn stuff away. You can't be like this."