I've been taking Wellbutrin for many years starting when my husband had cancer. I had to increase the dose after he died, then reduced the dose years later only to have to increase again after other traumatic events - 2 sons have died, home fire with complete loss, more losses than is helpful to go into just to say that the depression following all of it just persisted. I did wean off it this past year after it had been 3 years since the last son died only to find out just how low I felt and how lost I felt and displaced without the life I used to have. I have remarried and have a very nice life but I still have a broken heart. I haven't been willing to do SSRIs because I know just how hard they are to get off and the side effects aren't worth it. The Wellbutrin works well for me. To me it's about the quality of life. I want to have some quality as best I can. I do still have a daughter and 3 grandchildren, a wonderful husband and surprisingly, my health.