Prednisone taken only in the morning does not last long enough to help during the night. I find taking most of my current regular dose in the morning and then a smaller dose in the evening helps it last longer and it helps during the night. I know many others have reported doing that also. But you need to have a variety of dose sizes to help with this. I have 5 mg, 2.5 mg and 1 mg tablets for the stage that I am in. Someone else may need 10s or 20s, etc.