Of all the drugs I was put on (all that you list plus more) none worked except Entyvio , in fact I had bad reactions to most.

Entyvio worked well for about 6 months then tapered off and started the worst flare I ever had.

So what's my advice? In my experience when something didn't work or stopped working I said done, next! Only you can decide when that happens.

Another suggestion I have is Never, EVER think a second opinion is wrong or will hurt someones feelings. It's your body. Each time I got a second opinion I got the answers and information I needed to make an informed decision on my next course of treatment.

For me the battle was lost so I opted for a total proctocolectomy, which was absolutely the best medical decision I have ever made. I got my life back and no drugs. It wasn't all rainbows and unicorns, but looking back at where I was in the summer of 17 to now, I pick now.

Please ask if you have questions. I'll go back through my records and help you with anything I can.